烯二炔（Enediyne）一般是指具有共轭的炔-烯-炔结构的一类化合物。 含有九或十元环共轭烯二炔骨架结构的天然产物具有很强的抗癌和抗菌作用，但因不稳定且有毒性，很少用于临床。 其抗癌抗菌机制主要是烯二炔发生Bergman环化反应生成的1,4-去氢苯双自由基（对苯炔），从DNA上夺取氢原子从而使DNA发生裂解。

Enediynes are organic compounds containing two triple bonds and one double bond. The term is usually used to describe a class of bacterial natural products characterized by either nine- and ten-membered rings in which the double bond lies between the two triple bonds. Many of these compounds are capable of undergoing Bergman cyclization. The resulting diradical, a 1,4-dehydrobenzene derivative, is capable of abstracting hydrogen atoms from the sugar backbone of DNA which results in strand scission. This high reactivity with DNA makes the substances toxic. They are being researched as antitumor agents. Several of the naturally occurring enediynes have entered clinical trials against cancer and in Japan neocarzinostatin is used clinically.