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词汇 VDJ recombination
分类 英语词汇 英语翻译词典
释义

VDJ recombination

中文百科

J节段 V(D)J recombination

(重定向自VDJ recombination)

J节段 (连接节段) 是免疫球蛋白和T细胞受体基因座中的编码串行。J节段介于可变基因节段(V) 和恒定基因节段(C) 之间。

英语百科

V(D)J recombination J节段

(重定向自VDJ recombination)
Simplistic overview of V(D)J recombination of immunoglobulin heavy chains
Esquema simplificado de la recombinación V(D)J de las cadenas de inmunoglobulina.

V(D)J recombination, less commonly known as somatic recombination, is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. The process results in the highly diverse repertoire of antibodies/immunoglobulins (Igs) and T cell receptors (TCRs) found on B cells and T cells, respectively. The process is a defining feature of the adaptive immune system and its development was a key event in the evolution of jawed vertebrates.

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