主业会（拉丁语：Opus Dei），亦称主业团。其拉丁语原名直译为「天主的事工」，另一个有名的称呼是圣十字架及主业社团（Sanctae Crucis et Operis Dei； Prelature of the Holy Cross and Opus Dei）。该组织是一个天主教的自治社团，其正式的组织规格为个人监督区（personal prelature）或称属人监督团，其使命为鼓励社会各个层面的基督徒在俗世的生活中与他的信仰要能完全吻合实践，并且将基督的福音传播至全球及社会的各个层面及角落。其构成成员有天主教平信徒以及属于该团体的在俗司铎，由一位监督管理。监督是由会规规范于出缺时开办选举大会后推举出一位神父并由教宗同意后接任，除创办人施礼华外，其首位及现任监督都有被教宗任命为主教。

Opus Dei, formally known as The Prelature of the Holy Cross and Opus Dei (Latin:Praelatura Sanctae Crucis et Operis Dei), is an institution of the Roman Catholic Church that teaches that everyone is called to holiness and that ordinary life is a path to sanctity. The majority of its membership are lay people, with secular priests under the governance of a prelate (bishop) elected by specific members and appointed by the Pope. Opus Dei is Latin for "Work of God"; hence the organization is often referred to by members and supporters as the Work.