Motretinide
![Motretinide synthesis: W. Bollag et al.,DE 2414619 ; eidem, U.S. Patent 4,215,215 (1974, 1980 both to Hoffmann-La Roche).](/Images/godic/202501/28/Motretinide_synthesis.svg1151.png")
Motretinide is an anti-acne preparation and aromatic analog of retinoic acid.
The keratolytic analogue motretinide is effective in treating acne and the excess epithelilial growth characeteristic of psoriasis, demonstrating that an aromatic terminal ring is compatible with activity. The synthesis passes through the related orally active antipsoriatic/antitumor agent etretinate (3). These synthetic compounds have a wider safety margin than the natural materials.