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词汇 Cyclooxygenase 2
分类 英语词汇 英语翻译词典
释义

Cyclooxygenase 2

原声例句
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In 1976, researchers discovered cyclooxygenase, or the COX enzyme, which makes a few different biomarkers, including prostaglandins.

1976 年,研究人员发现了环氧合酶,即 COX 酶,它产生了几种不同的生物标志物,包括前列腺素。

英语百科

Prostaglandin-endoperoxide synthase 2

(重定向自Cyclooxygenase 2)
 Arachidonic acid bound to the PTGS2 (COX-2) enzyme. polar interactions between Archidonic Acid (cyan) and Ser-530 and Tyr-385 residues are shown with yellow dashed lines. The substrate is stabilized by hydrophobic interactions.[6]
 Mechanism of COX activation and catalysis. A hydroperoxide oxidizes the heme  to a ferryl-oxo derivative that either is reduced in the first step of the peroxidase cycle or oxidizes Tyrosine 385 to a tyrosyl radical. The tyrosyl radical can then oxidize the 13-pro(S) hydrogen of arachidonic acid to initiate the COX  cycle.

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. Because the "COX" term is used for the stem symbol for "cytochrome c oxidase" family of genes and gene products including proteins, the "PTGS" symbol is used for the prostaglandin-endoperoxide synthase (cyclooxygenase) family of genes and proteins. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin and thromboxane A2, among others.

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