So gene therapies are fantastic for diseases that can be attributed to a single gene mutation or single root cause.

因此，对于可归因于单一基因突变或单一根本原因的疾病，基因疗法非常有效。

There is clear evidence that a single gene mutation can lead to obesity, such as, for instance, leptin deficiency and POMC deficiency.

有明确的证据表明，单个基因突变会导致肥胖，例如瘦素缺乏和 POMC 缺乏。