RPTN

RPTN is a gene that encodes the protein repetin. Repetin is an extracellular epidermal matrix protein. RPTN is part of the S-100 protein family and contains a EF hand structural domain.

RPTN is one of the genes that differ between present-day humans and Neanderthals. It functions in the cornified cell envelope formation. It is a multifunctional epidermal matrix protein. RPTN reversibly binds calcium.