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词汇 Pseudomonic acid
分类 英语词汇 英语翻译词典
释义

Pseudomonic acid

中文百科

莫匹罗星 Mupirocin

（重定向自Pseudomonic acid）

莫匹罗星（英文：Mupirocin）是一种外用抗生素类抗感染药。

莫匹罗星又称假单胞菌酸A，由荧光假单胞菌(Pseudomonas fluorescens)分离出。

英语百科

Mupirocin 莫匹罗星

（重定向自Pseudomonic acid）
Ball-and-stick model of the mupirocin molecule
Figure 1. The domain structure of MmpA, MmpC, and MmpD for the synthesis of monic acid. The biosynthesis of monic acid is not colinear but has been rearranged in this diagram. The protein name is displayed inside of the arrow with module and domain structure listed below. ACP=acyl carrier protein, AT=acyl transferase, DH=dehydratase, ER=enoyl reductase, HMG=3-hydroxy-3-methylglutaric acid, MeT=methyl transferase, KR=ketoreductase, KS=ketosynthase, TE=thioesterase.
Figure 2. The structure of pseudomonic acid A-D, labeled A-D, respectively.
Figure 4. The pyran ring of mupirocin is generated in this proposed multistep reaction [15]. Gene knockouts of mupO, mupU, mupV and macpE abolish PA-A production but not PA-B production, demonstrating that PA-B is a precursor to PA-A.[19]

Mupirocin (trade names Bactroban, Centany) is an antibiotic. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is inactive for most anaerobic bacteria, mycobacteria, mycoplasma, chlamydia, yeast and fungi.
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