在计算机技术的历史中，宏病毒(英语：Macro virus)是一种使得应用软件的相关应用文档内含有被称为宏的可执行代码的病毒。一个电子表格程序可能允许用户在一个文档中嵌入“宏命令”，使得某种操作得以自动运行；同样的操作也就可以将病毒嵌入电子表格来对用户的使用造成破坏。

在1990年代中后期最流行的病毒就是和微软公司办公软件（如Microsoft Word及Excel）相关的宏病毒。在90年代后期，微软公司的电子邮件软件Outlook（拥有scripting特性）成为传播宏病毒最常用的载体。直到今天还是如此。Outlook的scripting特性使得宏病毒能够获得Outlook用户地址簿中存储的联系人地址，通过向这些地址发送E-mail将病毒体广泛传播。而之前的电脑病毒（比如Morris电脑病毒）同样通过E-mail传播，但破坏力远不及此。

In computing terminology, a macro virus is a virus that is written in a macro language: a programming language which is embedded inside a software application (e.g., word processors and spreadsheet applications). Some applications, such as Microsoft Office, allow macro programs to be embedded in documents such that the macros are run automatically when the document is opened, and this provides a distinct mechanism by which malicious computer instructions can spread. This is one reason it can be dangerous to open unexpected attachments in e-mails. Many antivirus programs can detect macro viruses, however they are still difficult to detect.