The flat was really very nice, but compared with what we'd been used to, it was a terrible let-down.这套公寓真的很不错，但比起我们以往住的地方，那就差太远了。The sense of let-down today is all the greater because in the past doctors have been over-confident about these treatments.医生们过去对这些疗法过度自信，导致今天的挫败感尤其强烈。