Disease from surrounding structures can invade the masticator space via the pterygopalatine fossa, the buccal space immediately anterior to the ramus, the foramen ovale, or by way of direct invasion.

咀嚼肌间隙临近的病变可循翼腭窝、颊间隙、上颌窦、卵圆孔等途径侵及咀嚼肌间隙。