Phosphopantothenoylcysteine decarboxylase

In enzymology, a phosphopantothenoylcysteine decarboxylase (EC4.1.1.36) is an enzyme that catalyzes the chemical reaction

Hence, this enzyme has one substrate, , and two products, pantotheine 4'-phosphate and CO₂.

This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). Other names in common use include 4-phosphopantotheoylcysteine decarboxylase, 4-phosphopantothenoyl-L-cysteine decarboxylase, PPC-decarboxylase, and N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase. This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.