Detection limit
（重定向自Limit of quantitation）
![Illustration of the concept of detection limit and quantitation limit by showing the theoretical normal distributions associated with blank, detection limit, and quantification limit level samples..](/Images/godic/202501/24/LOD4447.png")
In analytical chemistry, the detection limit, lower limit of detection, or LOD (limit of detection), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) within a stated confidence limit (generally 1%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.