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词汇 Knockout mice
分类 英语词汇 英语翻译词典
释义

Knockout mice

中文百科

基因剔除小鼠 Knockout mouse

（重定向自Knockout mice）

基因剔除小鼠是一种遗传工程技术下利用基因剔除技术所做出的一或多个基因变异的小鼠。广义来说，当小鼠体内的特定基因被剔除称之。此技术为用来观察并研究活体内基因表现的工具之一。此外，更可借由基因剔除后对小鼠所产生的变化，精确地了解人类先天基因缺损所造成疾病的致病机转，也是此技术的重大优点之一。

英语百科

Knockout mouse 基因剔除小鼠

（重定向自Knockout mice）
A laboratory mouse in which a gene affecting hair growth has been knocked out (left), is shown next to a normal lab mouse.
A knockout mouse (left) that is a model for obesity, compared with a normal mouse.
The procedure for making mixed-genotype blastocyst.
Breeding scheme for producing knockout mice. Blastocysts containing cells, that are both wildtype and knockout cells, are injected into the uterus of a foster mother. This produces offspring that are either wildtype and coloured the same colour as the blastocyst donor (grey) or chimera (mixed) and partially knocked out. The chimera mice are crossed with a normal wildtype mouse (grey). This produces offspring that are either white and heterozygous for the knocked out gene or grey and wildtype. White heterozygous mice can subsequently be crossed to produce mice that are homozygous for the knocked out gene.

A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
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