克莱恩-莱文综合症（英语：Kleine-Levin syndrome，简称为KLS），或俗称睡美人病，是一种罕见的神经系统异常。主要特征为嗜睡，患者会连续睡上好几周，甚至是好几个月，沉睡期间除了自己醒来吃东西、喝水之外，任何事都叫不醒他。待这段沉睡期过了之后，患者会不记得这段期间发生的事。很多患者说道，他们对所有事失去注意力，对声音和光非常敏感。女性患者中有部分会产生抑郁

Kleine–Levin syndrome (KLS) also known as "Sleeping Beauty syndrome" is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Many patients also experience hyperphagia, hypersexuality and other symptoms. Patients generally experience recurrent episodes of the condition for more than a decade. Individual episodes generally last more than a week but less than a month. The condition greatly affects the personal, professional, and social lives of sufferers, but symptoms spontaneously resolve and seldom cause permanent issues. The severity of symptoms and the course of the disease vary between sufferers. Patients commonly have about 20 episodes over about a decade. Several months generally elapse between episodes. The onset of the condition usually follows a viral infection; several different viruses have been observed to trigger KLS. It is generally only diagnosed after similar conditions have been excluded; MRI, CT scans, lumbar puncture, and toxicology tests are used to rule out other possibilities. The disease's mechanism is not known, but the thalamus is thought to possibly play a role. Tomography has shown hypoperfusion in the brains of patients during episodes.