卡塞塞是乌干达的城镇，位于该国西南部，由卡塞塞区负责管辖，距离首都坎帕拉约350公里，海拔高度约1,000米，镇上有机场设施，2011年人口估计74,300。

Kasese is a town in the Western Region of Uganda, lying north of Lake George. It originally grew around the copper mine at Kilembe, while attention later turned to cobalt mining. It is the chief town of Kasese District, and the district headquarters are located there. Kasese is also the largest town in Rwenzururu region, and Charles Mumbere, the king of Rwenzururu, maintains a palace in the town.