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词汇 Growth cones
分类 英语词汇 英语翻译词典
释义

Growth cones

英语百科

Growth cone

(重定向自Growth cones)
Image of a fluorescently-labeled growth cone extending from an axon F-actin (red) microtubules (green).
Two fluorescently-labeled growth cones. The growth cone (green) on the left is an example of a “filopodial” growth cone, while the one on the right is a “lamellipodial” growth cone.  Typically, growth cones have both structures, but with varying sizes and numbers of each.
Model of growth cone-mediated axon guidance. From left to right, this model describes how the cytoskeleton responds and reorganizes to grow towards a positive stimulus (+) detected by receptors in the growth cone or away from a negative stimulus (-).
Cellules de crêtes neurales en culture in vitro en train de migrer grâce à leurs lamellipodes.

A growth cone is a dynamic, actin-supported extension of a developing neurite seeking its synaptic target. Their existence was originally proposed by Spanish histologist Santiago Ramón y Cajal based upon stationary images he observed under the microscope. He first described the growth cone based on fixed cells as “a concentration of protoplasm of conical form, endowed with amoeboid movements” (Cajal, 1890). Neuronal growth cones are situated on the very tips of nerve cells on structures called axons and dendrites. The sensory, motor, integrative, and adaptive functions of growing axons and dendrites are all contained within this specialized structure.

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