Anzano di Puglia is a small town and comune in the province of Foggia and region of Apulia in southeast Italy.

According to the results of the national census made in 1991 Anzano di Puglia had a population of 2,239 inhabitants (Anzanesi), a surface of 11.12 square kilometres (4.29 sq mi) and a population density of 201.3 inhabitants per square kilometer. It rises 760 metres (2,490 ft) above sea level. By 2008 the population had fallen to 1,972.