Umbellulone
![](/Images/godic/202502/18/Umbellulone.svg2739.png")
![Space-filling model of umbellulone.](/Images/godic/202502/18/Spacefilling2739.png")
![Figure 2: (A) Strucutural formula according to Tutin, 1908. (B) Structural formula according to Semmller, 1908.](/Images/godic/202502/18/Structuurfomules_umbellulone2739.png")
![Figure 3: Reaction between cysteamine and umbellulone.](/Images/godic/202502/18/Reactie_mechanisme2739.png")
Umbellulone is a headache-inducing monoterpene ketone found in the leaves of the tree Umbellularia californica, sometimes known as the "headache tree".
It is hypothesized to cause headaches by influencing the trigeminovascular system via TRPA1.