Synucleinopathies

Synucleinopathies (also called α-Synucleinopathies) are neurodegenerative diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. One prevailing hypothesis has been that the death of dopaminergic cells is the proximate cause of functional deficits. However, introduction of exogenous α-SYN in a rodent animal model has been shown to induce functional deficits preceding cell death.