蘑菇科（学名：Agaricaceae）是担子菌门下伞菌目的一科，包含了伞菌属及其他原先被分类作其他科的品种，合共85个属、1340个品种。

白环蘑属（Leucoagaricus）跟白鬼伞属（Leucocoprinus）这两个属均已知与蚂蚁共生。The extinct genus Coprinites is one of four known agaricalean genera in the fossil record.Others include Aureofungus, Protomycena, and Archaeomarasmius. Archaeomarasmius leggeti, from Atlantic Coastal Plain amber, is 90–94 Ma); the other fossil genera are from Dominican amber and date to 15–20 Ma.

The Agaricaceae are a family of basidiomycete fungi and includes the genus Agaricus, as well as basidiomycetes previously classified in the families Tulostomataceae, Lepiotaceae, and Lycoperdaceae.