圣胡安德拉马瓜纳是中美洲国家多米尼加共和国的城市，也是圣胡安省的首府，位于该国西部，距离首都圣多明哥200公里，始建于1503年，面积1,876.21平方公里，海拔高度415米，2012年人口139,032。

San Juan dela Maguana is the capital municipality and the largest city in the province of San Juan, in the western region of the Dominican Republic. It was one of the first cities founded on the island; founded in 1503 and was given the name of San Juan de la Maguana by San Juan Bautista and the Taino name of the valley: Maguana. The term Maguana means "the first stone, the unique stone".