San Fratello (Gallo-Italic: San Frareau, Sicilian: Santu Frateddu, Greek and Latin: Apollonia, Medieval Latin Castrum S. Philadelphi), formerly San Filadelfio, is a comune (municipality) in the Province of Messina in the Italian region Sicily, located about 110 kilometres (68 mi) east of Palermo and about 90 kilometres (56 mi) west of Messina. San Fratello borders the following municipalities: Acquedolci, Alcara li Fusi, Caronia, Cesarò, Militello Rosmarino, Sant'Agata di Militello.