Pizzighettone is a comune of the Province of Cremona in the Italian region Lombardy. The main population centre is located on the river Adda and is divided into two parts: Pizzighettone on the east bank and Gera on the west.

It was the site of the Insubrian town of Acerrae, and was home to the football team A.S. Pizzighettone, until the summer 2012 when it moved to city of Crema and changed its name to U.S. Pergolettese 1932.