潘加尼河（Pangani River）是坦桑尼亚东北部的河流，发源自乞力马扎罗山，流经吉佩湖，最终在潘加尼注入印度洋，河道全长500公里，流域面积56,300平方公里。

The Pangani River (pin-gi'nee) (also called Luffu and Jipe Ruvu, especially in older sources, and probably once called Rhaptus) is a major river of northeastern Tanzania. It has two main sources: the Ruvu, which rises as Lumi at Kilimanjaro, passes through Lake Jipe, and empties into the Nyumba ya Mungu Reservoir, and the Kikuletwa, coming from the west and mainly fed by Mount Meru, which also enters into the Nyumba ya Mungu Reservoir. Just after leaving the reservoir the stream becomes the Pangani, which empties into the Indian Ocean at the town of Pangani.