埃索美拉唑(英语：Esomeprazole)是氢离子帮浦阻断剂，商品名为耐适恩(英语：Nexium)；由阿斯利康研发并在瑞典上市。用于治疗消化不良、消化性溃疡、胃食管反流病及柔林格症候群(Zollinger-Ellison syndrome)

Esomeprazole sold under the brand name Nexium among others, is a proton pump inhibitor which reduces stomach acid. It is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.

It decreases secretion of acid through inhibition of the H/K-ATPase in the parietal cells of the stomach. By inhibiting the functioning of this transporter, the drug prevents formation of stomach acid.