Leucine dehydrogenase
In enzymology, a leucine dehydrogenase (EC1.4.1.9) is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are L-leucine, H2O, and NAD, whereas its 4 products are 4-methyl-2-oxopentanoate, NH3, NADH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-leucine:NAD+ oxidoreductase (deaminating). Other names in common use include L-leucine dehydrogenase, L-leucine:NAD+ oxidoreductase, deaminating, and LeuDH. This enzyme participates in valine, leucine and isoleucine degradation and valine, leucine and isoleucine biosynthesis.