Thrombophilia
（重定向自Hypercoagulability）
![](/Images/godic/202501/19/DVTUS0522.PNG")
![A right-sided acute deep vein thrombosis (to the left in the image). The leg is swollen and red due to venous outflow obstruction.](/Images/godic/202501/19/Deep_vein_thrombosis_of_the_right_leg0523.jpg")
![The coagulation system, often described as a](/Images/godic/202501/19/Coagulation_full.svg0523.png")
![A mutation of coagulation factor V (schematic representation drawn here) is much more common in people with thrombosis than in those without, but is only regarded as a weak risk factor.](/Images/godic/202501/19/Protein_F5_PDB_1czs0523.png")
Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). Such abnormalities can be identified in 50% of people who have an episode of thrombosis (such as deep vein thrombosis in the leg) that was not provoked by other causes. A significant proportion of the population has a detectable abnormality, but most of these only develop thrombosis in the presence of an additional risk factor.