古利斯坦是乌兹别克斯坦的城市，也是锡尔河州的首府，位于该国东部，距离首都塔什干120公里，海拔高度271米，主要经济活动是棉花业，2009年人口67,846。

Guliston also spelled as Gulistan (Uzbek:Guliston / Гулистoн; Russian:Гулистан), formerly known as Mirzachul (Russian: Мирзачуль, until 1961), is the capital of Sirdaryo Region in eastern Uzbekistan. It lies in the southeastern part of the Mirzachül (formerly Golodnaya) steppe, 75 miles (120 km) southwest of Tashkent. It has an approx. population of 77,300. The main industry in the area is cottonpicking.