埃塞奎博河（Essequibo River）是圭亚那最长的河流，发源于圭巴边境的阿卡里山，向北流经圭亚那全境，最终注入大西洋，全长约1010公里。

The Essequibo River (Spanish:Río Esequibo) is the largest river in Guyana, and the largest river between the Orinoco and Amazon. Rising in the Acarai Mountains near the Brazil-Guyana-Venezuela border, the Essequibo flows to the north for 1,010 kilometres (630 mi) through forest and savanna into the Atlantic Ocean.