Campofranco (Campufrancu in Sicilian) is a comune (municipality) in the Province of Caltanissetta in the Italian region Sicily, located about 70 kilometres (43mi) southeast of Palermo and about 35 kilometres (22mi) west of Caltanissetta. As of 31 December 2004, it had a population of 3,491 and an area of 36.0 square kilometres (13.9sqmi).