If allopurinol toxicity occurs, options include other xanthine oxidase inhibitors, a uricosuric agent, or allopurinol desensitisation (the latter only in cases of mild rash). 如出现药物毒性,其他选择包括其他黄嘌呤氧化酶抑制剂、促进尿酸排泄药或脱敏疗法(后者仅适于轻度皮疹者)。
Uricosuric medications, like probenecid, increase excretion of uric acid by the kidneys.
促尿酸排泄药物,如丙磺舒,会提高尿酸的肾脏排泄。
英语百科
Uricosuric
Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the kidney. Drugs that reduce blood uric acid are not all uricosurics; blood uric acid can be reduced by other mechanisms (see other Antigout medications).