Selective glucocorticoid receptor modulator

（重定向自SEGRA）

The benzopyranoquinoline A 276575, an example of a SEGRA with a more corticosteroid-like structure[6]

Simplified overview of the mechanism of action of a classical glucocorticoid vs the mechanism of action of a SEGRAM

RU 24858, a SEGRA with steroid structure[5]

Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs but with fewer side effects such as skin atrophy. Although preclinical evidence on SEGRAMs’ anti-inflammatory effects are culminating, currently, the efficacy of these SEGRAMs on cancer are largely unknown.

词汇	SEGRA
分类	英语词汇英语翻译词典
释义	SEGRA 英语百科 Selective glucocorticoid receptor modulator （重定向自SEGRA） Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs but with fewer side effects such as skin atrophy. Although preclinical evidence on SEGRAMs’ anti-inflammatory effects are culminating, currently, the efficacy of these SEGRAMs on cancer are largely unknown.
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