Priolo Gargallo (Sicilian: Priolu) is a comune (municipality) in the Province of Syracuse, Sicily (Italy). It is about 190 kilometres (120mi) southeast of Palermo and about 13 kilometres (8mi) northwest of Syracuse. As of 31 December 2004, it had a population of 12,009 and an area of 57.6 square kilometres (22.2sqmi).