In the second stage, the primary follicles develop into secondary and eventually tertiary, or graafian follicles.
第二阶段,初级卵泡形成次级卵泡,最终形成第三极卵泡,即格拉夫卵泡。
Osmosis-解剖与生理
Meanwhile, the primordial follicle turns into a primary follicle, meaning that the follicular cells that surrounding the primary oocyte develop into granulosa cells.
与此同时,包围初级卵母细胞的滤泡细胞分化为颗粒细胞,使始基卵泡变为初级卵泡。
Osmosis-血液肿瘤
Other activated B-cells go to the center of a primary follicle in the lymph node and they differentiate into B-cells called centroblasts and start to proliferate or divide.
其它活化的B细胞进入淋巴结的初级滤泡中心,然后分化成中心母细胞,并开始增殖或分裂。
Osmosis-解剖与生理
The second stage of follicular development begins for a few lucky primary follicles with the first menstrual cycle in puberty, and a few more primary follicles go into the second stage with each subsequent menstrual cycle.
Germinal centers or germinal centres (GC) are sites within secondary lymphoid organs where mature B lymphocytes proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation), and switch the class of their antibodies (for example from IgM to IgG) during a normal immune response to an infection. They develop dynamically after the activation of follicular (Fo) B cells by T-dependent antigen.