Opiliaceae is a family of flowering plants. It consists of tropical woody plants. Several genera contain parasitic species. The biggest genus, in number of species and in stature of the individual plants, is Agonandra, the only American genus.

Since it was first described this family has been recognized universally by taxonomists. The APG II system, of 2003 (unchanged from the APG system, of 1998), also recognizes this family and assigns it to the order Santalales in the clade core eudicots.