It was an act of the utmost bravery and disregard for personal safety.这行动需要极大的勇气，并把个人安危置之度外。He had shown himself to be careless of personal safety where the life of his colleagues might be at risk.在同事的生命可能受到威胁时，他将个人安危置之度外。She can shrug off her troubles and keep smiling.她能够把烦恼置之度外而依旧保持笑容。