马塔蒂勒是南非的城镇，位于该国东部，由东开普省负责管辖，距离科克斯塔德70公里，面积6.74平方公里，2001年人口5,214，人口密度每平方公里770人。

Matatiele is a mid-sized town serving the farming and trading communities of East Griqualand in the foothills of the western Drakensberg, Eastern Cape, South Africa, on the border with KwaZulu-Natal and 20 km from the southern frontier of Lesotho. Dairy farming is the principal activity. Good trout fishing is to be had in the numerous streams of the area. As a town, Matatiele is the reference point for all of the northern Transkei.