Luteinizing hormone/choriogonadotropin receptor
![](/Images/godic/202501/25/PBB_GE_LHCGR_207240_s_at_tn5650.png")
![Luteinizing hormone up-regulates cholesterol side chain cleaving enzyme in sensitive tissues, the first step of all human steroidogenesis.](/Images/godic/202501/25/Steroidogenesis.svg5650.png")
![The seven transmembrane α-helix structure of a G protein-coupled receptor such as LHCGR](/Images/godic/202501/25/7TM_receptor5650.png")
The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR) is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction.