Jumping library
![This figure illustrates the basic principle behind jumping libraries.The arrows represent two physically distant sequences which are brought closer together using this method.](/Images/godic/202501/21/Figure_1_Basic_Principle_of_a_Jumping_Library2627.png")
![This figure is a schematic representation of the method used for creating jumping libraries when it was originally developed in the 80s.](/Images/godic/202501/21/Figure_2_Original_method_for_creating_a_jumping_library2627.png")
![This figure is schematic representation of one of the most recently used methods for creating jumping libraries.](/Images/godic/202501/21/Figure_3_Recent_method_for_creating_a_jumping_library2627.png")
Jumping libraries or junction-fragment libraries are collections of genomic DNA fragments generated by chromosome jumping. These libraries allow us to analyze large areas of the genome and overcome distance limitations in common cloning techniques. A jumping library clone is composed of two stretches of DNA that are usually located many kilobases away from each other. The stretch of DNA located between these two “ends” is deleted by a series of biochemical manipulations carried out at the start of this cloning technique.