10-Formyltetrahydrofolate
（重定向自Formyltetrahydrofolates）
![Skeletal formula of 10-formyltetrahydrofolate](/Images/godic/202501/14/10-formyl-tetrahydrofolic_acid.svg0242.png")
![Space-filling model of the 10-formyltetrahydrofolate molecule](/Images/godic/202501/14/10-Formyltetrahydrofolate-3D-spacefill0242.png")
![](/Images/godic/202501/14/5,10-Methenyltetrahydrofolate.svg0242.png")
![](/Images/godic/202501/14/Tetrahydrofolic_acid.svg0242.png")
10-Formyltetrahydrofolate (10-CHO-THF) is a form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions. This is important in purine biosynthesis, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase, as well as in the formylation of the methionyl initiator tRNA (fMet-tRNA), when 10-CHO-THF is a substrate for methionyl-tRNA formyltransferase.