We have had to contend with the disinterest of much of the medical profession about this topic.我们必须全力对付很多医疗界人士对这一话题的冷漠。There were too many problems to contend with.要全力对付的问题真是太多太多了。His wife's ill health is something he has to contend with.妻子的病体是他必须全力对付的事情。