β-Lactamase

Core structure of penicillins (top) and cephalosporins (bottom). β-lactam ring in red.

Escherichia coli bacteria on the right are sensitive to two beta-lactam antibiotics, and do not grow in the semi-circular regions surrounding the antibiotics. E. coli bacteria on the left are resistant to beta-lactam antibiotics, and grow next to one antibiotic (bottom) and are less inhibited by another antibiotic (top).

Beta-lactamases are enzymes (EC3.5.2.6) produced by bacteria(Also known as Penicillinase ) that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the lactamase enzyme breaks the β-lactam ring open, deactivating the molecule's antibacterial properties.

词汇	ESBL
分类	英语词汇英语翻译词典
释义	ESBL 原声例句 Osmosis-微生物 It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production. 肺炎克雷伯杆菌也是一种多重耐药菌，如果产生β-内酰胺酶，可以用头孢菌素、氨基糖苷类、氟喹诺酮类以及碳青霉烯类药物治疗；如果产生ESBL，可以只应用碳青霉烯类进行治疗；如果产生碳青霉烯酶，则应用多粘菌素、替加环素或磷霉素进行治疗。英语百科 β-Lactamase Beta-lactamases are enzymes (EC3.5.2.6) produced by bacteria(Also known as Penicillinase ) that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the lactamase enzyme breaks the β-lactam ring open, deactivating the molecule's antibacterial properties.
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ESBL

β-Lactamase