CREB
（重定向自CAMP response element binding protein）
![CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression.](/Images/godic/202501/02/CREB4147.png")
![General structure of the CREB protein.](/Images/godic/202501/02/CREB_protein4147.png")
CREB (cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.