Callosa de Segura (Spanish pronunciation: [kaˈʎosa ðe seˈɣuɾa]) is a municipality in the comarca of Vega Baja del Segura in the Valencian Community, Spain. It contains the historic monument of the Church of St Martin.

Callosa de Segura is a traditional Spanish-speaking town located north-west of Orihuela. It can be reached via the A-7 (E15) motorway, junction 79, or from the AP-7 motorway, junction 733 and is situated just 30 minutes from Alicante and Murcia airports and 30 minutes from Guardamar beach.