Bottromycin
![](/Images/godic/202501/01/Chemical_structure_of_bottromycin_A22938.png")
![Schematic of the mechanism of action of bottromycin](/Images/godic/202501/01/Bottromycin_mechanism_of_action22938.png")
![The three-dimensional solution structure of bottromycin A2, based on data from Gouda, et al.[5] Oxygen, bright blue; nitrogen, red; sulfur, yellow; main chain, green](/Images/godic/202501/01/Bottromycin_A2_3D_Structure2938.png")
![Annotated bottromycin biosynthetic gene cluster in S. bottropensis[16]](/Images/godic/202501/01/S._bottropensis_bottromycin_biosynthetic_cluster22938.png")
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.