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词汇 VMAT
分类 英语词汇 英语翻译词典
释义

VMAT

英语百科

Vesicular monoamine transporter

(重定向自VMAT)
A Hydrogen atom from the inside of the vesicle binds, inducing a conformational change in the transporter
The conformational change induced by the hydrogen atom binding enables the monoamine binding to the active transport site
A second hydrogen atom binds from inside the vesicle to the transporter inducing another change
The monoamine is released inside the vesicle and the two hydrogen atoms are released into the cytosol and the transport process starts over again.

The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of presynaptic neurons. It acts to transport monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses as chemical messages to postsynaptic neurons. VMATs utilize a proton gradient generated by V-ATPases in vesicle membranes to power monoamine import.

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