Thiazolidinedione
（重定向自TZD）
![Functional group](/Images/godic/202502/18/Thiazolidinedione_functional_group.svg3421.png")
![Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects.](/Images/godic/202502/18/Transactivation_upload.svg3421.png")
![Thiazolidinedione ligand dependent transrepression mediates the majority of anti-inflammatory effects.](/Images/godic/202502/18/PPAR_transrepression.svg3421.png")
![The chemical structure of thiazolidinedione and rhodanine](/Images/godic/202502/18/Thiazolidinedione_and_rhodanine.svg3421.png")
The thiazolidinediones /θaɪ.əˌzoʊlᵻdiːnˈdaɪ.oʊn/, also known as glitazones, are a class of medications used in the treatment of diabetes mellitus type 2. They were introduced in the late 1990s. They contain a functional group in which thiazolidine serves as a dione.