外用药物(Topical medication)，在医学中，是使用于身体表面例如皮肤或是一些黏膜上，像是阴道，咽喉，阴茎，眼睛和耳朵等。

某些疏水性化学物质例如类固醇激素在以药膏，凝胶或乳液的形式使用在皮肤上之后可以被吸收到身体里。皮肤贴片已经在为了避孕，绝经期女性补充雌性激素和防止晕动病方面成为服用药越来越普遍的一种方式。

在牙医学中，外用药物也可以用来指使用于牙齿表面的药物。

氯霉素是抗生素中外用药物的一个例子。

A topical medication is a medication that is applied to a particular place on or in the body, as opposed to systemically. (The word topical derives from Greek topikos, "of a place".) Most often this means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments.