Aldosterone escape

In physiology, aldosterone escape is a term that has been used to refer to two distinct phenomena involving aldosterone that are exactly opposite each other:

In patients with hyperaldosteronism, chronic exposure to excess aldosterone does not cause edema as might be expected. Aldosterone initially results in an increase in Na reabsorption in these patients through stimulation of ENaC channels in principal cells of the renal collecting tubules. Increased ENaC channels situated in the apical membranes of the principal cells allow for more Na reabsorption, which may cause a transient increase in fluid reabsorption as well. However, within a few days, Na reabsorption returns to normal as evidenced by normal urinary Na levels in these patients.